Cardinals vs. Chiefs score: Live updates, game stats, highlights as Kyler Murray and Patrick Mahomes face off

The Arizona Cardinals and Kansas City Chiefs kicked off at University of Phoenix Stadium on Sunday for an AFC vs. NFC showdown. Both teams are coming off disappointing playoff losses last season, with the Chiefs losing to the Cincinnati Bengals in overtime in the AFC Championship and the Cardinals getting blasted by the Los Angeles Rams in the Wild Card Round.

Cardinals quarterback Kyler Murray has a lot to prove this season after signing a five-year, $230.5 million extension.

Things will be a bit rough for Murray to start the season as he is without star receiver DeAndre Hopkins, who is suspended for violating the league’s drug policy.

The Chiefs have Patrick Mahomes leading their offense and as long as that is the case they are a threat to any team in the league.

Mahomes, like Murray, will be without one of his most trusted players, Tyreek Hill, who left Kansas City for the Miami Dolphins this offseason. Mahomes still has tight end Travis Kelce and Juju Smith-Schuster making his Chiefs debut.

Both teams have high expectations going into the 2022 NFL season and facing another top team in the league will be a good test for either team.

How to watch

  • When: Sunday at 4:25 p.m. ET
  • Where: State Farm Stadium – Glendale, Arizona
  • TV: SCS
  • Online broadcast: Paramount+
  • Follow: CBS Sports app
  • Odds: Heads -6.5, O/U 54

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